POLYCYTHAEMIA VERA AND CHRISTMAS DISEASE WITH SLIGHTLY PROLONGED PROTHROMBIN TIME

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Polycythaemia vera and Christmas disease with slightly prolonged prothrombin time.

A family is reported in which Christmas disease in one member and polycythaemia in another were associated with prolongations of the one-stage prothrombin time of the factor-VII deficiency type. Changes in the prothrombin time were present in the siblings of the case of Christmas disease and in a number of unrelated cases of polycythaemia vera. The use of "mixing procedures" did not reveal any ...

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Polycythaemia vera (PV) can be defined as a myeloproliferative neoplasm (MPN) with erythrocytosis and JAK2V617F (or an equivalent marker of clonality). While these simple criteria are sufficient for most cases of overt PV, an estimated 10–15% of PV patients do not have an elevated haemoglobin concentration (Hb) and may mimic JAK2-positive essential thrombocythaemia (ET). This poses a problem fo...

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Peripheral gangrene in polycythaemia vera.

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1960

ISSN: 0021-9746

DOI: 10.1136/jcp.13.4.299